Modeling

A number of observations have lent support to a model in which thermal stress is transduced into a signal at the level of the cellular membranes. Our alternative, but not exclusive, approach is based on the concept that the initial stress-sensing events are associated with the physical state and lipid composition of cellular membranes, i.e., the subtle alteration(s) of membrane fluidity, phase state, and/or microheterogeneity may operate as a cellular thermometer. In fact, various pathological states and aging are associated with typical “membrane defects” and simultaneous dysregulation of heat shock protein synthesis. The discovery of nonproteotoxic membrane-lipid interacting compounds, capable of modulating membrane microdomains engaged in primary stress sensing may be of paramount importance for the design of new drugs with the ability to induce or attenuate the level of particular heat shock proteins.

Selected publications

Differential effect of 2-hydroxyoleic acid enantiomers on protein (sphingomyelin synthase) and lipid (membrane) targets
S Piotto, S Concilio, E Bianchino, P Iannelli, DJ López, S Terés, ...
Biochimica et Biophysica Acta (BBA)-Biomembranes 2014

Small azobenzene derivatives active against bacteria and fungi
S Piotto, S Concilio, L Sessa, A Porta, EC Calabrese, A Zanfardino, ...
European journal of medicinal chemistry 68, 178-184 2013

2-Hydroxy Arachidonic Acid: A New Non-Steroidal Anti-Inflammatory Drug
DH Lopez, MA Fiol-deRoque, MA Noguera-Salvà, S Terés, F Campana, ...
PloS one 8 (8), e72052 2013

Antioxidant activity of diphenylpropionamide derivatives: Synthesis, biological evaluation and computational analysis
P Urbani, A Ramunno, R Filosa, A Pinto, A Popolo, E Bianchino, S Piotto, ...
Molecules 13 (4), 749-761 2008